Hepatitis C genotype 1 is generally the most serious, and it is recommended that patients need to actively receive treatment. Hepatitis C genotyping is usually categorized into six types: type 1, type 2, type 3, type 4, type 5 and type 6, of which type 1b and type 2a are the main ones in our clinic and type 1b is often difficult to cure. Genotyping is a prerequisite for the treatment of hepatitis C, as the treatment cycle and medication selection are often different for different genotypes. In the case of the refractory type, the standard course of treatment is usually 48 weeks, and it is important that the full course of treatment is carried out to avoid recurrent episodes. At the same time, hepatitis C has a certain degree of harm, if the disease is not effectively controlled, the progress of the disease may cause cirrhosis or even cause liver cancer, so it is necessary to be actively treated under the guidance of specialists.