If the cause of pericardial effusion cannot be found, the first thing you need to do is to adjust your daily routine and have regular heart checkups, and you can treat the symptoms according to the specific symptoms. 1. Adjusting lifestyle: In a small percentage of cases where the cause of pericardial effusion cannot be identified, it can be considered to be a stress reaction caused by a combination of factors such as work and rest, diet and so on. Improving your lifestyle and developing a healthy routine can help regulate your immune system and gradually improve your pericardial effusion. 2. Regular medical checkups: If the cause of pericardial effusion cannot be determined, it may be due to the lack of clear symptoms of infection and damage. Regular cardiac checkups with electrocardiograms, ultrasounds, or punctures can be used to follow up on the health of the heart. 3. Symptomatic treatment: When the cause of the pericardial effusion cannot be determined, symptomatic treatment of complications can be performed. Drainage by puncture can be performed when symptoms such as dyspnea or pericardial tamponade are present. When pericardial effusion causes complications such as leukocytosis or fever, initial anti-infective therapy may be considered under the supervision of a physician to observe the efficacy of the treatment, and medications such as acyclovir or ribavirin may be chosen as prescribed by the physician. If the cause of pericardial effusion cannot be determined, it is recommended to maintain a healthy lifestyle and diet, have regular medical checkups, and follow the doctor’s instructions without self-medication.