If there is pericardial effusion in esophageal cancer (esophageal cancer), pericardial effusion caused by cancer needs pericardiocentesis and drainage and treatment for esophageal cancer; if pericardial effusion is caused by other reasons, it is necessary to clarify the cause of pericardial effusion and treat the cause. 1. Pericardiocentesis and drainage: pericardial effusion caused by esophageal cancer suggests that the patient’s esophageal cancer stage is late and the prognosis is poor, and the pericardial effusion may cause pericardial occlusion and lead to cardiac arrest which may jeopardize the patient’s life, so it is necessary to carry out pericardiocentesis and drainage to drain out the fluid in the pericardium. 2. Treatment for esophageal cancer: pericardial effusion caused by esophageal cancer is mainly treated for esophageal cancer, such as surgery and radiotherapy. Usually, radical surgery is preferred, and if the patient cannot be cured, palliative surgery can be chosen. After surgery, adjuvant radiotherapy and chemotherapy can effectively improve the prognosis and prolong the life span of the patient, and drugs such as cisplatin and paclitaxel are commonly used for chemotherapy. 3. Pericardial effusion of other causes: Pericardial effusion may be caused by heart disease, lung disease, etc., and it is necessary to find out the cause of the disease and then treat the cause. If pericardial effusion is found in esophageal cancer, it is recommended to consult hospital in time. Patients may suffer from shortness of breath, dyspnea, chest pain with pressure sensation, which is more serious and needs professional doctor’s guidance for treatment. Drugs should be used under the guidance of doctors.