Treatment of pericardial effusion includes medication and surgery. The fastest and most effective treatment should be formulated according to the patient’s condition. 1. Drug therapy: it is suitable for patients whose condition is stable and will not have pericardial pressure for the time being. Commonly used drugs are non-steroidal anti-inflammatory drugs and diuretics. (1) Non-steroidal anti-inflammatory drugs: for example, ibuprofen, indomethacin, etc. The purpose is to reduce the patient’s pain symptoms. (2) Diuretics: such as spironolactone, furosemide, etc., are used to reduce the symptoms of edema and decrease the amount of increase in fluid accumulation. 2. Surgical treatment: Surgical methods include pericardiocentesis tube placement and drainage, transthoracic pericardiectomy, thoracoscopic pericardial opening and drainage, and pericardiosclerosis. (1) Pericardiocentesis tube drainage: release the fluid and improve the related symptoms. (2) Transthoracic pericardiectomy: improve cardiac function by removing the pericardium. (3) Thoracoscopic pericardiocentesis: to remove fibrous exudate from the pericardial cavity and reduce the risk of recurrence of pericardial effusion. (4) Pericardiosclerosis: for recurrent intractable pericardial effusion so that fluid cannot accumulate inside the pericardium. If pericardial effusion occurs, it is recommended to consult a doctor in time and develop the most appropriate treatment plan according to the patient’s own condition under the guidance of the doctor.