Hypopituitarism (Simon-Sihan syndrome) is a clinical syndrome that presents with inadequate secretion of adenohypophyseal hormones due to multiple etiologies, secondary to hypogonadal, thyroid, and adrenocortical function. In Silhan syndrome, the gonads are hypogonadal and the ovaries are significantly reduced in women. The uterus and mammary glands are atrophied. The secretion of various hormones is drastically reduced due to adenopituitary lesions, and there is insufficient secretion of thyroid hormones, adrenocortical hormones, and sex hormones. The compensatory function of the pituitary gland is strong, and there are no clinical symptoms when the dead range is <50%, and very slight clinical symptoms when it is >75%, and there are obvious symptoms only when the tissue necrosis exceeds 90%, and the symptoms are severe when the destruction area reaches 95%. The onset of the disease is mostly in the 20-40 years of age of childbearing, amenorrhea can occur 3 months to 32 years after delivery, more in menstruating women than in primiparous women, and more in rural than in urban areas. The clinical manifestation of the corresponding target organ hypofunction is not completely parallel, with different early and late onset and different severity of symptoms, and the early symptoms are slight and not easily diagnosed. Typical patients manifest as follows: in the puerperium after postpartum hemorrhagic shock, long-term senile weakness, earliest as no lactation, then secondary amenorrhea, even if menstruation resumes, it is often scanty and secondary to infertility. Decreased sexual desire, vaginal dryness, and difficulty in coitus. Loss of pubic and axillary hair, thinning of hair and eyebrows, atrophy of breasts and genitalia, mental apathy, drowsiness, inactivity, unresponsiveness, chilliness, absence of sweating, dry and rough skin, loss of appetite, little food, constipation, low body temperature, slow pulse, reduced blood pressure, pallor, anemia. Most patients have edema and weight loss, and a few have wasting cachexia. With a history of postpartum hemorrhage or shock, the diagnosis can be confirmed by the above typical clinical manifestations and signs, combined with laboratory tests.