Postoperative complications, such as postoperative hemorrhage, anastomotic fistula, secondary infection, recurrence and metastasis of colon cancer, are the most feared complications after colon cancer surgery. 1. Postoperative hemorrhage: postoperative hemorrhage is mainly caused by the large blood vessels in the abdominal cavity not being firmly ligated during the operation, shedding of thread knots and large amount of blood oozing from the trauma, and postoperative hemorrhage should be stopped immediately by open abdominal surgery. 2. anastomotic fistula: when the anastomosis place fistula, digestive fluid will enter the chest cavity or abdominal cavity, easy to cause infection, serious cases can be life-threatening. If the fistula is small, it can be treated conservatively under the guidance of the physician, such as water fasting and fasting, etc. And with antibiotic drugs to prevent intestinal bleeding. And with antibiotic drugs to prevent intestinal infections, such as azithromycin, roxithromycin and so on. If the fistula is large, it is necessary to carry out a second surgery. 3. Secondary infection: when patients have anastomotic fistula, it is also easy to stimulate infection, and in serious cases, infectious shock will occur, which is life-threatening. When infection occurs after colon cancer surgery, it should be treated with cephalosporin antibiotics under doctor’s instruction, such as cefepime, cefpirome and so on. 4. Recurrence and metastasis of colon cancer: cancer cells may recur and metastasize to liver, lung, bone and other parts of the body after colon cancer surgery, and it should be recommended to prefer capecitabine monotherapy or continuous infusion of 5-fluorouracil or calcium folinate under the guidance of professional physicians, and chemotherapy should be carried out synchronously during the long course radiotherapy. In summary, after colon cancer surgery, it is necessary to actively follow the medical advice to reduce the occurrence of postoperative complications, improve the quality of survival and prolong the survival period.