There is such a disease: very common, 6 out of every 100 people suffer from this disease, and the incidence is still rising year by year; very unfamiliar, most patients have never heard of it; taken lightly, although more than 70% of patients are suffering from the disease’s serious intrusion, but most people often choose to endure for years, self-management, the active medical rate of less than 10%; easy to misdiagnosis, more hidden, half of the patients do not know that they have the disease …… This is “GERD”. The typical symptoms of GERD are acid reflux, regurgitation, and heartburn (burning sensation in the retrosternal region), but some patients are always asymptomatic or have atypical symptoms (extraesophageal symptoms) such as cough, wheezing, dry and itchy throat, foreign body sensation in the throat, and hoarseness, which are often overlooked. Many patients have a recurrent cough, a feeling of something stuck in the throat, nausea and dry vomiting when brushing their teeth in the morning, or difficulty in breathing due to spasms in the larynx during sleep at night, easily waking up in the middle of the night due to breath-holding, and even nausea and heartburn. These symptoms often mislead patients to think that they are suffering from “pharyngitis” or “asthma”, while ignoring the real cause of the disease. Gastroenterologists suggest that if you have a persistent chronic cough of unknown origin, frequent nocturnal episodes, asthma (non-allergic) and retrosternal discomfort in adulthood, but no organic lesions are detected in the relevant departments and the disease remains untreated, you should be alert to the possibility of gastroesophageal reflux disease.