There are many causes of stomach discomfort and bitter mouth, commonly caused by cholecystitis, gastroesophageal reflux disease, peptic ulcer and other lesions, different treatments can be used for different diseases. 1, cholecystitis: patients with cholecystitis can cause stomach discomfort after eating greasy food, prone to bile reflux leading to bitter mouth symptoms, and may be accompanied by abdominal distension, indigestion and other manifestations, can be under the guidance of a doctor oral choleretic drugs, such as Magnesium sulfate, dehydrocholic acid tablets, etc. for treatment. At the same time, we should pay attention to the diet, more easily digestible food, such as porridge, noodles, millet porridge, rice porridge, corn porridge, etc., avoid eating some cold, greasy, spicy and irritating food; 2, gastroesophageal reflux disease: pyloric sphincter muscle function is weakened, the duodenum of bile reflux into the stomach caused by chronic gastritis gastroesophageal reflux patients, can appear uncomfortable stomach, bitter mouth symptoms. Can follow medical advice to use drugs to reduce gastric acid, promote gastric power, enhance gastric mucosal protection, such as omeprazole, cimetidine, famotidine, aluminum thioglycollate, etc., to relieve stomach discomfort; 3, peptic ulcer: such as gastric ulcer, duodenal ulcer, etc., usually caused by H. pylori infection, resulting in gastrointestinal power deficiency, triggering stomach discomfort, while H. pylori secretion of urease decomposition of carbon dioxide, ammonia It can cause symptoms of bad taste in the mouth and bitterness in the mouth. The H. pylori infection should be actively treated, often using quadruple therapy, that is, two antibiotics combined with proton pump inhibitors, bismuth together, proton pump inhibitors often choose omeprazole, rabeprazole, bismuth often choose bismuth pectin, bismuth potassium citrate, antibiotics can be used amoxicillin, clarithromycin, metronidazole, etc.