Not interested in anything may be two diseases, one disease is depression, and the other disease may be a prodromal symptom of schizophrenia, as follows: I. Depression: The main manifestation of depression is low mood, patients are not happy, things that used to interest them are not interested now, they are not willing to do anything, their motivation is relatively poor, one of its core symptoms is not interested in anything, and There is no happy experience. If a person shows no interest in anything, it is important to consider whether he or she is suffering from depression. Second, the prodromal symptoms of schizophrenia: especially in severe mental illnesses, the most prominent manifestations at the beginning are poor interpersonal interaction, indifference to people, detachment from society, less emotional involvement, or even emotional numbness, and disinterest in doing things that last longer and longer, which can seriously impair the patient’s social functioning. In the long run, a series of serious psychotic symptoms may appear, such as relationship delusions, delusions of victimization, hallucinations, etc. The lack of interest in anything may also be the result of a stressful event and not always a disease. There are some people who are under a lot of stress, for example, facing the pressure of midterm and college entrance exams, and they may show no interest in anything, and there are even some people who only focus on study and work, and their main interest lies in study and work, and they are not interested in anything else.