Gastroscopy pylorus closure is normal, but there is bile reflux, can not be ruled out that there may be Helicobacter pylori infection, gastric motility decline and chronic cholecystitis induced, need to be actively treated. 1. Helicobacter pylori infection: Helicobacter pylori infection may induce the appearance of bile reflux symptoms, will cause bile reflux gastritis, accompanied by bitter mouth, nausea and acid reflux, as well as a slight and abdominal pain and other symptoms, and need to be actively treated. 2. Decreased gastric motility: it can cause paroxysmal bloating and epigastric pain, etc. With the help of gastroscopy, congestion, swelling and even bile reflux can be observed in the mucosa of the stomach. 3. Chronic cholecystitis: through gastroscopy, it can be observed that inflammatory factors lead to adverse stimulation of the gastric mucosa, which may also induce acid reflux and bile reflux. It is recommended that the patient’s discomfort to the regular hospital to receive further examination and treatment, to avoid delaying the condition affects the health of the body.