Drinking Coke with coffee is not harmful to the normal population, but drinking a large amount of it for a long time may increase the risk of dental caries and obesity; for people with heart disease, diabetes, gastric ulcers and other diseases, it may aggravate the symptoms of the disease and is not conducive to disease control. For normal adults, appropriate consumption of cola with coffee is not too harmful, but cola is a carbonated beverage, containing more sugar, ordinary coffee in the sugar content is also higher, long-term large-scale drinking may increase the risk of dental caries, obesity and other risks. In addition, cola and coffee contain caffeine, for patients with heart disease may induce premature beats, increased heart rate, etc.; in gastric ulcer, gastroesophageal reflux patients may aggravate the symptoms of gastric discomfort, affecting the recovery of the disease; the drink contains a large amount of sugar, diabetic patients drink on the blood glucose impact, is not conducive to the stabilization of blood glucose. Therefore, if you have been in good health, you can drink Coke with coffee appropriately, but if there is underlying disease or discomfort after drinking, it is recommended to avoid drinking.