Stage IV lung adenocarcinoma with bone metastasis can be treated by radiotherapy, chemotherapy, targeted therapy, immunotherapy and anti-bone metastasis therapy. 1. Radiotherapy: using radiation to irradiate metastatic tumor or primary tumor including bone metastatic lesions can kill cancer cells and control tumor progression. 2. Chemotherapy: Pemetrexed, nedaplatin, paclitaxel and other cytotoxic chemotherapeutic drugs are transported through the blood to reach all parts of the body to kill cancer cells in all parts of the body, including bone metastases. 3. Targeted therapy: patients with stage IV lung adenocarcinoma with specific gene mutations such as EGFR, ALK, etc., which are detected by genetic test, can take targeted drugs such as ositinib and ceritinib to kill the cancer cells accurately. It has the advantages of good efficacy and small side effects. 4. Immunotherapy: using immune checkpoint inhibitors such as Sindilizumab and Tirilizumab can inhibit cancer cells from evading the immune system. Using autoimmune system to kill cancer cells in stage IV lung adenocarcinoma with bone metastasis as well as in the whole body. 5. Anti-bone metastasis treatment: For bone metastases of stage IV lung adenocarcinoma, drugs to enhance bone density such as deslizumab and zoledronic acid can be used to inhibit cancer cells from destroying the bone quality. If the bone quality of the bone metastasis is fragile, bone cement can also be injected to reinforce it and prevent pathological fracture. There are many ways to treat stage IV lung adenocarcinoma bone metastasis, which can prolong the survival period and reduce the pain of patients, and should be carried out under the guidance of doctors. Please strictly follow the doctor’s instruction for drug treatment and do not use drugs by yourself.