The total bilirubin in blood is the sum of unconjugated bilirubin and conjugated bilirubin, either or both of which can cause a high total bilirubin value, causing a high total bilirubin for the following reasons: 1. The former is mainly due to excessive destruction of red blood cells caused by hemolysis, while the latter is mostly due to ineffective hematopoiesis and excessive bilirubin production. 2, non-conjugated bilirubin and conjugated bilirubin are both elevated mainly due to hepatocyte dysfunction, causing impaired uptake, conjugation or excretion of bilirubin, resulting in elevated bilirubin. 3.The causes of elevated total bilirubin and conjugated bilirubin are mainly due to the obstruction of bilirubin excretion in the biliary system, biliary tract obstruction, and conjugated bilirubin cannot be excreted to the intestine, so the conjugated bilirubin in the blood is elevated. Elevated bilirubin can cause jaundice, whether it is dominant jaundice or recessive jaundice, which can cause certain harm to the human body, especially non-conjugated bilirubin has a special affinity for the nervous system and can cause nuclear jaundice. Once elevated bilirubin in the blood is found, the cause of elevated bilirubin should be actively identified for early treatment.