The main manifestation of allergic conjunctivitis is a strange itchy eye, which, unlike ordinary itching, is often very intense and unbearable. The incidence of itchy eyes is 99% to 100%, and the incidence of foreign body sensation is 72% to 80%. In infants and young children, eye rubbing and tearing are the main complaints of parents. The clinical manifestations are diffuse conjunctival congestion, edema, papillary and follicular hyperplasia, changes in conjunctival color of the bulbar conjunctiva and the dome, periocular cyanosis, and in severe cases, corneal epithelial infiltration and ulcer formation. Itchy eyes, lacrimation, photophobia, foreign body sensation, recurrent eye redness, morning mucous-like discharge, sneezing, and runny eyes are the main symptoms, with itchy eyes (incidence 99%-100%) and foreign body sensation (incidence 72%-80%). There are also children with allergic conjunctivitis with cough and general malaise as the main symptoms. IgE-mediated ocular inflammation Inspired by allergens, IgE-mediated ocular inflammatory diseases, mainly caused by type I hypersensitivity reactions, are non-infectious ocular surface diseases in children. When allergens enter the eye and bind to IgE out of the mast cells of the conjunctiva, activation of the mast cells leads to an allergic response and the release of multiple inflammatory mediators, including histamine, trypsin-like enzymes, prostaglandins, leukotrienes, chemokines, and other vasoreactivating factors. These histamines cause local dilation of small blood vessels and produce symptoms of redness, swelling and itching. The onset and development of allergic reactions are closely related to TH1/TH2 imbalance, manifested by a dominant TH2 type expression. Specific IgE antibody immunotherapy is currently the only treatment modality that may alter the natural course of type I allergic reactions through immunomodulatory mechanisms, producing good overall efficacy compared to drug therapy and effectively improving the quality of life of patients with allergic rhinitis.