The redness and itchiness after the use of tretinoin cream is because of the allergy to tretinoin cream, at this time the patient should stop the drug in time, wash the affected area with water, if necessary, oral cetirizine and other anti-allergy drugs for treatment. Patients in the use of tretinoin cream during the skin redness and itchy symptoms, considering that the patient is allergic to the drug components of tretinoin cream. Patients will experience allergic symptoms such as itchy skin, red skin rash, and in severe cases, symptoms such as respiratory distress or even shock. Patients should immediately stop using Tretinoin Neomycin Paste and promptly rinse off the ointment that has been applied to the skin with water. If the symptoms of red and itchy skin are not relieved after treatment, you can follow the doctor’s instructions to take oral levocetirizine and other anti-allergy drugs to treat. When patients have red and itchy skin after using tretinoin cream, it is recommended to stop taking the medicine to wash and go to the hospital, follow the doctor’s instructions to deal with as well as medication.