Stratum corneum thickening mainly refers to keratinization-like changes in the most superficial part of the skin epidermis, which can result in many symptoms such as hardening of the epidermis and reduced tactile sensation. If you want to improve this symptom, it is recommended that you can choose to use topical ointments to get rid of it, you can apply compound lactic acid cream, compound salicylic acid cream, etc. Acidic ointment applied to the surface of the local stratum corneum can effectively soften the stratum corneum, you can also choose to use laser to remove it, can make the thickened stratum corneum gradually fall off, for skin repair has a certain improvement effect. Under normal circumstances long-term itching and scratching will lead to the thickening of the stratum corneum. The main focus is to remove the itching, you can apply hydrocortisone butyrate ointment or compound chlorhexidine acetate spray, can effectively relieve itching and prevent the cuticle from thickening again.