If the mother has hepatitis B, the newborn needs to be injected with hepatitis B vaccine and immunoglobulin, and if the mother does not have hepatitis B, the newborn only needs to be injected with hepatitis B vaccine. When the mother has hepatitis B, the probability of newborns being infected with hepatitis B increases, and the timely injection of hepatitis B immunoglobulin and hepatitis B vaccine at birth can strengthen the resistance, which can reduce the chances of newborns being infected with hepatitis B. If the mother does not have hepatitis B, the newborns only need to be injected with hepatitis B vaccine for routine prevention. If the mother does not have hepatitis B, the newborn only needs to be injected with hepatitis B vaccine at birth for routine prophylaxis, and does not need to be injected with hepatitis B immunoglobulin. It is recommended to ask the clinician, who will decide whether immunoglobulin is needed based on the condition of the newborn.