The sequelae after craniotomy for epidural hematoma are treated on a case-by-case basis, and each person’s condition determines the sequelae differently. The most common sequelae are epilepsy, because the epidural hematoma, which can compress the brain tissue, and the process of craniotomy, may also damage the surrounding brain tissue, creating a process of abnormal intracranial discharge. After the surgery, if the corresponding epilepsy prevention treatment is not carried out in time, it is easy to cause epilepsy and must be actively prevented after the surgery. There is also intracranial infection, because after craniotomy, certainly a part of the outside bacteria will enter the cranium, if not actively carry out anti-infection preventive treatment, it is easy to cause such adverse reactions, therefore, after surgery must be timely observation of changes in the condition, early corresponding treatment. It can also cause numbness, weakness and speech dysfunction of the limbs, because when the epidural hematoma appears, it will compress the surrounding brain tissue, especially if the compression time is too long, it is easy to produce nerve necrosis, thus causing a series of complications such as numbness and weakness of the limbs and hemiparesis.