A positive hepatitis B core antibody is not necessarily hepatitis B. It may also be a result of a previous infection with the hepatitis B virus, or the patient may be in the stage of an acute hepatitis B infection or an acute exacerbation of chronic hepatitis B. The two main types of hepatitis B core antibodies include hepatitis B core antibody immunoglobulin G (IgG) and hepatitis B core antibody immunoglobulin M (IgM). Patients who have been infected with the hepatitis B virus in the past may show a single positive hepatitis B core antibody (mainly IgG), while the remaining four are negative, indicating that the virus has been cleared from the patient’s body and he/she is in the recovery stage. However, some patients with a high level of hepatitis B core antibody positivity may still have a low level of viral replication in their bodies, and they need to enhance their nutrition and exercise appropriately in order to prevent the recurrence of hepatitis B. For a single hepatitis B core antibody IgM positive and the remaining 4 negative, it may be that the patient is in an acute hepatitis B infection or an acute exacerbation of chronic hepatitis B. The patient’s blood is infectious at this time. At this time, the patient’s blood is infectious and needs to be further analyzed in combination with liver function and virus quantification. When hepatitis B core antibody is positive, and at the same time hepatitis B expression antigen, hepatitis B e antigen and hepatitis B e antibody are positive, it is generally acute and chronic hepatitis B, and it is infectious, usually need to be given antiviral treatment. If the patient’s test result is positive for hepatitis B core antibody, it should be further analyzed by the doctor according to the patient’s symptoms, medical history, other auxiliary tests, etc. The patient should not rely on a single test indicator to judge by himself.