The statement of which one is effective, Methylcobalamin or Glutamine, is not scientific, Glutamine and Methylcobalamin are two different kinds of drugs and their therapeutic effects are different, therefore, there is no good or bad difference between Methylcobalamin and Glutamine. Methylcobalamin is a kind of drug for treating peripheral neuropathy, and its common dosage forms are capsules, tablets, dispersible tablets, injections, etc. It can be used in the treatment of peripheral neuropathy as well as megaloblastic anemia caused by vitamin B12 deficiency. Glutamine is a kind of mesencephalic function regulating drug, and the common dosage forms are tablets and injections, which can be used for the treatment of autonomic dysfunction, primary dysmenorrhea, premenstrual tension, menopausal syndrome and so on. As the components of methylcobalamin and glutamine are different, the mechanism of action and indications of the two drugs are also different, the role of methylcobalamin is to nourish the nerves, glutamine is to regulate the nerves, usually there is no good or bad effect of methylcobalamin and glutamine.