What to do when creatinine is at the critical value: First, pay attention to protecting the kidneys to avoid further creatinine elevation, pay attention to rest, avoid straining, avoid staying up late and using nephrotoxic drugs, and also pay attention to adding and removing clothes in time to avoid infection and diarrhea. Second, to find out the cause of creatinine in the critical value, the most common clinical diseases that cause creatinine elevation are chronic glomerulonephritis, hypertensive nephropathy and diabetic nephropathy. For patients with hypertensive nephropathy and diabetic nephropathy, the most important thing is to actively regulate blood pressure and blood glucose, you can take oral antihypertensive and hypoglycemic drugs, for example, antihypertensive drugs such as calcium channel antagonists, beta-blockers, diuretics, priligy or sartan drugs, hypoglycemic drugs are commonly used in clinical settings such as Reglanet, Gliquidone and Metformin. Third, for patients whose creatinine is at the critical value, they should visit the hospital regularly and closely monitor creatinine, endogenous creatinine clearance, as well as urine routine, urine microalbumin and other related tests, so as to actively cooperate with the doctor’s treatment.