Blood creatinine, is one of the common clinical indicators to evaluate the good or bad kidney function. The higher creatinine means the more serious kidney function is damaged, and a large part of kidney disease patients’ concern about the disease status is on the creatinine value. What exactly is creatinine? Creatinine is one of the metabolites in human body. Under normal circumstances, creatinine is produced in muscles, which enters the kidneys with blood circulation and is excreted out of the body through urine, called endogenous creatinine. In addition, fish and meat protein food can also produce a small portion of exogenous creatinine. Therefore, the amount of creatinine produced in the body is different for people of different genders and different muscle contents, and the blood creatinine value is often different, about 60μmol/L for adult women and 80μmol/L for men, beyond which it indicates possible damage to kidney function. After the blood creatinine is elevated, will it decrease again? After creatinine is elevated, it can be lowered again, but only in a part of patients with acute kidney injury who are actively treated, creatinine can be restored to within the normal range and kidney function can be completely restored to normal, but some patients will turn to chronic kidney disease. In the case of patients with chronic kidney disease, the kidney function has been partly damaged and the excretory function is weakened, creatinine tends to be maintained in a stable range and will not be drastically reduced. If the blood creatinine value decreases significantly during the treatment, kidney patients should be alert to whether the treatment hospital is regular and reliable. Of course, there is also a part of kidney failure patients, the body toxins too high discomfort, need to increase the intestinal excretion of creatinine through Chinese medicine enema, colon dialysis, the use of medicinal charcoal tablets to reduce discomfort. Is the recurrence of blood creatinine a sign that kidney function is suddenly good or bad? There are often kidney disease patients who have their blood creatinine rising from 140 to 160 in the recheck, and then lowering to 140 in the next check, is it because the kidney function is bad or good? As mentioned before, kidney function cannot be recovered, and slight creatinine fluctuation does not mean that kidney function has changed. Creatinine will be affected by diet and muscle content, and the use of reducing glutathione and calcium hydroxybenzoate drugs will also interfere with the test results and make the creatinine value lower. When creatinine is ±10-20 repeatedly, kidney patients need not worry too much, but when creatinine continues to rise in small amounts, it needs to be taken seriously. In addition, it should be mentioned that due to the existence of test errors, the creatinine reference range of each hospital is not exactly the same, some hospitals have higher creatinine range values, kidney patients show elevated creatinine when referring to outside hospital ranges, which does not mean that kidney function is impaired. Kidney disease is afraid of elevated creatinine, so is the lower creatinine the better? Elevated blood creatinine often indicates deterioration of kidney function, therefore, many kidney patients pursue the lower creatinine the better, while chronic kidney disease patients with not high but low creatinine also exist, but this does not mean that their kidney function is better. Patients who are extremely lean, malnourished, and only eat vegetarian food for a long time have lower creatinine than ordinary people, and malnutrition can cause or aggravate chronic kidney disease patients with low immune function, anemia, infection, cardiovascular disease, gastrointestinal disease, etc. The low creatinine in such cases is often unfavorable more obviously. What should I do if my creatinine rises when taking ACEI and ARB drugs? ACEI, ARB class of antihypertensive drugs, is the kidney friends often eat Pulley, sartan class of antihypertensive drugs, they are commonly used by nephrologists, it can be said that almost all kidney disease patients have been or are taking, but such drugs are taken or dosed at the beginning will make creatinine rise 20%-30%, causing panic among kidney friends. In fact, panic is not necessary, although these two drugs can raise creatinine, but not the general drug produced by the kidney damage effect, but the normal reaction of the drug to take effect. Priligy or sartan drugs have a clear renal protective effect, used to reduce urine protein and blood pressure, although the blood creatinine is slightly elevated, but for the long-term prognosis of kidney disease patients is beneficial, kidney friends trust their doctors, according to the dosage of good. After all, I just want to tell you that creatinine does not look at a single test value but at the overall trend. If you don’t eat meat or take prescriptions to lower creatinine, you will only lower the creatinine value, which is harmful but not beneficial.