The clinical presentation of isolated plasmacytoma is characterized by a localized skeletal mass with pain. Isolated plasmacytoma is a rare plasma cell malignant tumor, which is pathologically characterized by clonally proliferating plasma cell infiltration, accounting for about 2% to 10% of all plasma cell tumors, including bone isolated plasmacytoma and extramedullary plasmacytoma, with the former being more common. Isolated plasmacytoma of bone mainly manifests as a single bone destruction, mostly seen in the central axis of the bone, such as the spine, pelvis, etc., and the age of prevalence is 55 years old on average. Specific symptoms are related to the site of onset, and its main clinical manifestations are mostly due to the pain caused by the destruction of the bone, or the symptoms of the compression of the spinal cord or the nerve roots caused by the swelling and the vertebral body involvement. Extramedullary plasmacytoma refers to plasma cell tumors that originate in areas other than bone marrow and bones. It mostly occurs in the head and neck, especially in the upper respiratory tract, and the common parts include nasal cavity, paranasal sinuses, nasopharynx, tonsils, and so on. Clinical symptoms include nasal congestion, epistaxis (nosebleed), hoarseness, hemoptysis, tearing, facial swelling, decreased sense of smell, dyspnea, etc., especially nasal congestion and epistaxis are the most common. If there is any abnormality or suspicion of confirmed diagnosis of isolated plasmacytoma, it is recommended to go to a regular hospital for comprehensive assessment of the condition, diagnose the disease by various means, and cooperate with the treatment as prescribed by the doctor, so as to avoid delaying the condition.