The reasons for urine protein to turn negative after two plus signs exist in the following cases. 1. for transient proteinuria, such as can occur after strenuous exercise in patients with long and lean body types. 2. a large amount of protein substances, such as lean meat, eggs, milk, peanuts, walnuts, beans and other protein substances, appearing transient high proteinuria, which can return to normal after paying attention to diet. 3. pathological conditions can also appear to gradually improve Possible, such as nephrotic syndrome, especially membranous nephropathy, 24hUP quantification less than 4 grams, 30% of patients also have the possibility of self-healing, that is, without any drug treatment, urine protein can turn negative. Other diseases, such as acute glomerulonephritis, can also be completely cured with treatment, depending on what kind of condition is causing the improvement.