Diabetic nephrotic syndrome is very difficult to cure, divided into the following cases: 1, diabetic kidney damage with a large amount of proteinuria, which causes nephrotic syndrome; 2, diabetes combined with the presence of other causes of kidney disease appears nephrotic syndrome; 3, diabetic nephropathy and other kidney disease at the same time. No matter which one is the case, it is not good to treat. The treatment of nephrotic syndrome caused by diabetes should be based on active blood sugar control and delaying the progress of the disease. If diabetes mellitus is combined with other kidney diseases, the nephrotic syndrome should be treated with diabetes mellitus and other kidney diseases. In the case of diabetic nephropathy combined with other diseases, treatment should be given to both diabetic nephropathy and the coexisting kidney disease.