Keratosis pilaris is a difficult to treat skin disease, often occurring in the palms of the hands and feet and joints on the extensor side, manifested as local hypertrophy, roughness and obvious mossification. Due to the long-term chronic inflammation of the skin infiltration, the course of the disease is long, itching is obvious, easy to recur, often chapped in winter. Keratosis pilaris eczema is commonly used halometasone cream, salicylic acid, retinoic acid, urea and cryotherapy and other forms of integrated treatment, the general treatment course is longer, and prone to recurrence. Patients with keratosis pilaris should pay attention to avoid scratching, hot water scalding and other aggravating factors in daily life, avoid all suspected causative factors, and keep the local skin lesions moisturized. Keratosis pilaris patients should go to the hospital in time, under the guidance of the doctor as soon as possible to carry out standardized treatment, to prevent further progression of the disease. Drugs should be used according to medical advice.