The vomiting and diarrhea that occurs the day after drinking is most often due to the disruption of the gastrointestinal tract caused by alcohol and the manifestation of acute gastroenteritis. In case of vomiting and diarrhea, blood tests and CRP should be completed to evaluate the indicators of inflammation. For the manifestation of vomiting, the drugs to be used are those that reduce the secretion of gastric acid and repair the mucosa of the stomach, which can be treated with Nexium and Membranoside. If the manifestation of diarrhea and diarrhea occurs repeatedly, montelukast can be used to stop diarrhea, and if necessary, medications to regulate intestinal flora, such as rectification of intestinal flora, should be used for treatment. If the diarrhea and vomiting are more serious, timely treatment such as IV rehydration should be carried out. Observe the changes of inflammatory indexes such as blood routine and CRP, and pay attention to the changes of abdominal symptoms and signs.