There are many causes of miscarriage, and the traditional view has always been that miscarriage is a woman’s business. With the development of medical science, especially male science, people have a better understanding of the possible role of the male partner in the miscarriage process: it turns out that the real cause of what used to be considered “unexplained” miscarriage is the male partner. It is well known that the chromosomes in the nucleus of the sperm carry the genetic code of the individual human being, and that when the human sperm and egg unite to form a fertilized egg, the sperm transmits the genetic information in the nucleus to the offspring to ensure the development of the embryo. Therefore, sperm chromosome aberrations or immature sperm nuclei can lead to abnormal embryo development or termination, and are the most common male factor causing miscarriage in women. Sperm chromatin DNA integrity test is one of the methods to evaluate the functional status of sperm nuclei. Men who live and work in an environment with high temperature, volatile chemical gases, noise and radiation for a long time will have poorer organism function and mental stress, which affects the function of sperm. If nodules with eggs, it may lead to miscarriage. If a man has varicocele, tumors, allergic diseases, persistent fever, etc.; or or orchitis, leukocytospermia, the sperm generated in this way is bound to be affected. We know that harmful chemicals can seriously endanger human health, such as benzene, mercury, cadmium, pesticides, etc. The harmful substances can be inhaled into the human blood through the lungs and can reach all parts of the body with the blood flow, which can affect the production of sperm and the quality of sperm, which in turn affects the growth and development of the embryo. Harmful substances can violate human nerve endings and affect human health.