Neck, shoulder, back and leg pain should first identify the cause of the disease, and then targeted physical therapy, drug therapy, surgical treatment, if the symptoms persist, it is recommended to seek medical attention in a timely manner. Causes of neck, shoulder, back and leg pain include overwork, chronic strain, osteoporosis, ankylosing spondylitis, etc. It is recommended to identify the cause of the disease before treatment and target treatment. 1. Overexertion: If you are tired of physical labor, it is easy to cause the accumulation of lactic acid in the body to cause neck, shoulder, waist and leg pain, you can take sufficient rest and appropriate hot compresses, can help to alleviate the pain. 2. Chronic strain: muscle stimulation by cold and other factors are prone to neck, shoulder, waist and leg pain, should pay attention to cold and warmth, adequate rest, the use of red light therapy to relieve pain, if necessary, under the guidance of the doctor to take ibuprofen and other drugs anti-inflammatory pain. 3. Osteoporosis: Osteoporosis is usually asymptomatic, but it is easy to cause bone fracture, you should take vitamin D and calcium tablets under the guidance of a doctor, if necessary, you can take bisphosphonates to inhibit bone resorption, and usually strengthen the nutritional support. 4. Ankylosing spondylitis: When ankylosing spondylitis is in acute attack, it can cause generalized discomfort. You can use drugs such as celecoxib to relieve pain, and you can also choose methotrexate to inhibit immune response, or you can use biological agents such as adalimumab to inhibit immune response. Causes of neck, shoulder, waist and leg pain are more reasons, may also be related to lumbar disc herniation, frozen shoulder, cervical spondylosis, osteophytes and other diseases, if there is no relief after resting, it is recommended to go to the hospital in a timely manner to find out the cause of the disease, and targeted treatment by the doctor. Medications should be used under the guidance of a doctor.