CT is the best way to visualize the pancreas and is highly reliable in determining pancreatic tissue abnormalities. 94% of positive diagnoses of pancreatic cancer are made by CT, and the smallest tumor diameter found is 1.0 cm. The initial evaluation should be performed by dynamic spiral or helical CT according to the prescribed pancreatic-specific protocol (triple tomography plus thin-section scanning). Imaging of pancreatic cancer is characterized by an enlarged pancreas with irregular contours and defects. The density of the lesion area is heterogeneous, often hypodense, or dense. Dilation of the pancreaticobiliary duct and enlargement of the gallbladder are often found in those with pancreatic head cancer. CT of pancreas combined with 3D reconstruction of blood vessels can show the relationship between tumor and blood vessels more clearly, and the accuracy of predicting resectability of tumor is about 80%, which is the best method for preoperative resectability assessment of pancreatic cancer. Ultrasound endoscopy (EUS) can examine the pancreas through the stomach and duodenal wall at close range, which not only avoids the influence of abdominal wall and gastrointestinal gas, but also greatly improves the discriminatory ability of the lesion. In terms of staging, EUS can be used as a complementary tool to CT and can provide valuable information on the staging of pancreatic cancer, especially for the evaluation of specific types of vascular invasion. eus can also be used to evaluate peri-pot belly masses and distinguish between infiltrative and non-invasive lesions. In addition, EUS can better identify cystic pancreatic lesions. On EUS, malignant cystic lesions may present as hypoechoic cystic/solid masses, or complex encapsulations, and are often associated with dilatation of the main pancreatic duct. In patients with resectable tumors, EUS-guided fine-needle aspiration (FNA) biopsy is superior to CT-guided FNA because of the lower risk of peritoneal seeding with EUS-FNA versus percutaneous approach biopsy. Some therapeutic interventions can also be performed with the aid of EUS (e.g., abdominal dry block, removal of peritoneal fluid). Endoscopic retrograde cholangiopancreatography (ERCP) has an important diagnostic value for pancreatic cancer. The main manifestations of pancreatic ductography in pancreatic cancer are main pancreatic duct stenosis, wall stiffness, dilatation, disruption, transposition and non-visualization or delayed emptying of contrast agent. ERCP is a useful diagnostic tool for patients with ambiguous CT findings because less than 3% of patients with pancreatic cancer may have normal pancreatic stenosis or significant proximal dilatation often suggesting malignant lesions.ERCP may be difficult to identify benign or malignant stenosis, but severe pancreatic duct stenosis or significant Stenting during ERCP can also reduce biliary obstruction when surgery is not possible or must be delayed. Magnetic Resonance Imaging (MRI) MRI has significant advantages in differentiating soft tissues, which has led to MRI gradually replacing CT scans in many areas of diagnostic imaging. Although MRI has not yet completely replaced CT scans in the diagnosis of pancreatic tumors, T1/T2-weighted MRI imaging and MRCP can provide comprehensive information about the primary lesion, the expansion of pancreaticobiliary duct obstruction, and the relationship between the tumor and large blood vessels. Used for preoperative imaging evaluation, enhanced MRI can be used in patients allergic to CT contrast agents and also as a complementary test to CT for better diagnosis of extra-pancreatic lesions. MRCP is also an alternative option if ERCP is not technically possible. Scanning technology has an important role in detecting occult tumor lesions throughout the body and can be used to detect earlier metastases. The role of PET-CT scans in the diagnosis of pancreatic cancer remains unclear. PET-CT is not a substitute for high-resolution enhanced CT. Percutaneous hepatobiliary cholangiopancreatography (PTC) is suitable for pancreatic cancer causing bile duct dilatation or jaundice, and post-implantation imaging is of high value in determining the site and nature of biliary obstruction, showing dilated bile ducts within and outside the liver, gallbladder enlargement, bile duct stricture, and bile duct stenosis. It can show dilatation of the bile ducts inside and outside the liver, enlargement of the gallbladder, bile duct stenosis, filling defect, interruption, displacement, and stiffness of the duct wall. After puncture, it is advisable to place a tube for bile drainage (PTCD) and perform preoperative yellowing reduction to prepare for surgery.