Sleep deprivation and sudden death are first considered to be due to lack of sleep, which induces the occurrence of arrhythmias. The patient is overworked, leading to disorders of the neurological function system. Also induced arrhythmias, usually ventricular fibrillation is common. When ventricular fibrillation occurs, the blood supply to the heart is severely affected and the heart experiences pump failure. Due to the sudden termination of blood ejection from the heart, resulting in a sudden interruption of blood supply to the vital organs of the body, the patient can experience sudden death. Secondly, the cause of sudden death due to sleep deprivation can also be considered as myocardial infarction. Patients with previous atherosclerosis and plaque in the lumen of blood vessels due to sleep deprivation can lead to the shedding of plaque, or the high-fat and high-viscosity state of blood, resulting in further increase of plaque, blocking blood vessels and sudden interruption of blood supply, and patients can also experience sudden death.