Whether blood creatinine over 500 μmol/L is serious depends mainly on the cause of its elevation. If acute kidney injury causes creatinine elevation, creatinine may return to normal after removing reversible factors, which may not be serious at this time; if chronic renal insufficiency causes creatinine elevation, serious complications such as hyperkalemia and acute left heart failure may occur, which is more serious at this time.
1. Acute kidney injury: If the acute kidney injury is caused by pre-renal factors such as volume insufficiency, renal artery stenosis, or post-renal factors such as urethral obstruction, and if the reversible factors are corrected, the creatinine level may gradually decrease or even return to normal, which is usually not serious at this time.
2. Chronic renal insufficiency: If chronic renal insufficiency is caused by organic damage of glomerulus itself, the damage of kidney is usually irreversible. Complications such as hyperkalemia and acute left heart failure may occur when blood creatinine exceeds 500μmol/L, which can be life-threatening and more serious at this time.
If patients find that the blood creatinine is elevated, it is recommended to go to regular hospitals in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment under the guidance of the doctor.