Scrotal surface peeling and flaking may be caused by physiological reasons such as dry skin, or it may be caused by pathological factors such as fungal infection, scrotal eczema, scrotal inflammation, atopic dermatitis, Behçet’s syndrome, etc., which need to be analyzed with specific problems. It is recommended that patients go to the hospital for further examination and symptomatic treatment after clarifying the cause. First, physiological reasons: due to the dry weather or their own excessive cleaning, can lead to the skin surface oil secretion is too little, which can cause the scrotum at the skin dry, appear peeling off flakes of skin. It is recommended not to over-clean the skin and apply lotion to moisturize the skin if necessary. Second, pathological reasons: 1, fungal infection: when patients do not pay attention to local hygiene and cleanliness, and if there is tinea pedis and other diseases, if the underpants and other clothing or socks together with the cleaning may cause fungal infection, which can lead to patients with the scrotum surface flaking skin, accompanied by local itchy symptoms, and its symptoms can be confined to the scrotum skin, but also can be to the inner thighs of the skin proliferation. It is recommended that patients go to the hospital for local fungal testing or skin testing, further diagnosis can be prescribed topical antifungal ointment, such as clotrimazole cream, etc. for treatment; 2, scrotal eczema: scrotal eczema is a common type of eczema, often associated with localized scrotal moisture, scrotal eczema can be confined to the skin of the scrotum, and sometimes extend to the anus around the penis, a few can be extended to the penis. When the patient suffers from scrotal eczema, the surface of the scrotum can appear peeling, flakes, or accompanied by red papules, superficial ulcers and other changes. Patients can follow the doctor’s instructions to use glycerine lotion for anti-itching treatment, if necessary, can take loratadine tablets, cetirizine hydrochloride tablets and other drugs to relieve the symptoms; 3, scrotal inflammation: scrotal inflammation refers to the scrotum skin and subcutaneous infections caused by inflammatory diseases, due to the male skin oil secretion, which can lead to the sebaceous glands, the hair follicles are clogged, so that inflammation occurs. The patient can appear scrotum local skin itching, pain, redness and swelling and other symptoms, if not timely treatment can lead to scrotum surface peeling, flakes. It is recommended that patients keep the local skin clean, do not scratch, so as not to cause secondary infection, if necessary, can follow the doctor’s instructions oral cefuroxime tablets, roxithromycin tablets and other medications for treatment; 4, allergic dermatitis: if the patient is allergic to rubber, lubricant components, in the sexual life of the scrotum in contact with such substances, there may be redness and swelling of the skin, skin rashes, itching and other allergic symptoms, but also may appear on the surface of the scrotum peeling, flaking skin and other manifestations. There may also be peeling and flaking of the scrotal surface. It is recommended that patients further check the allergens and stay away from allergens, and can take chlorpheniramine maleate tablets, loratadine tablets and other drugs for anti-allergy treatment as prescribed by the doctor; 5. Behcet’s syndrome: Behcet’s syndrome is a chronic systemic vasculitis of unclear etiology, and the patients not only have the symptoms mentioned above, but also may be accompanied by oral ulcers and ophthalmitis, which may recur, and other multi-system organ involvement can also be seen. Other multi-system organs are involved, such as the digestive system and cardiovascular system. When this symptom occurs, patients can take ibuprofen extended-release capsules, cyclophosphamide tablets and other drugs as prescribed by the doctor for treatment.