The incidence of diabetic nephropathy in China is on the rise, and now it has become the second pathogenic factor of end-stage renal failure. The trend of diabetic nephropathy is more youthful, and diabetic nephropathy is also more frequent, so the incidence of diabetic renal failure is also higher. Treatment should pay attention to the following aspects: 1, control blood sugar: glycosylated hemoglobin control below 7mmol/L; 2, control blood pressure: antihypertensive drugs preferred angiotensin converting enzyme inhibitors, such as enalapril, benazepril, or angiotensin receptor antagonists, including cloxacin potassium, valsartan, etc., with more proteinuria should control blood pressure at about 130/80mmHg; 3, renal function Early stage of renal failure can be treated with a combination of Chinese and Western medicine, and Chinese medicine treatment includes clearing heat and detoxification, activating blood circulation and removing blood stasis, and strengthening the spleen and relieving dampness; 4. Late stage can be treated with replacement therapy, including hemodialysis, peritoneal dialysis and transplantation. Transplantation can be performed in combination with simultaneous kidney and pancreas transplantation, which can improve the patient’s quality of life.