Reaching diabetic renal failure should belong to stage 4-5 of diabetic nephropathy. The symptoms are as follows: 1, diabetic nephropathy is a large amount of proteinuria, resulting in sclerosis of the glomerulus, the patient shows severe swelling, there will also be refractory hypertension, swelling can not be controlled with diuretics, its and chronic nephritis caused by kidney failure is not the same. Chronic nephritis will not show hypoproteinemia when renal failure finally occurs; 2. Patients with diabetic nephropathy will have uncontrollable hypoproteinemia, which will cause edema of both lower limbs, and in severe cases, there will be a large amount of fluid in the chest, pericardial cavity and abdominal cavity, i.e. plasma membrane cavity fluid. The above symptoms can only be treated symptomatically in accordance with chronic renal failure, when the residual kidney function needs to be protected, to a certain extent, the need for dialysis treatment, the indications for dialysis than the chronic nephritis-induced renal failure indications are wider, some patients may need to do dialysis at about 500 μmol/L creatinine. Patients with chronic nephritis need dialysis only when their creatinine is 600-700 μmol/L. Such patients need early treatment; 3. Other patients need to correct heart failure due to abnormalities in cardiac function.