Cheek bone pain can be treated clinically in different ways depending on the specific cause of the pain. If the pain is caused by acute septic infection in the oral cavity, such as gum abscess and tooth ulceration, it is necessary to actively control the oral infection, and oral metronidazole tablets can be taken. If the symptoms are serious, the ulcerated teeth can be extracted. After the infection in the mouth is controlled, the local pain symptoms can be gradually relieved. Secondly, cancer pain caused by malignant tumor in the oral cavity invading into the cheek bone, at this time, the patient’s pain often cannot be completely relieved by drugs, so it is recommended to improve the CT or MRI examination of the head to clarify the location and size of the tumor in the oral cavity and perform complete tumor removal. After surgery, combined with local radiotherapy and systemic chemotherapy to inhibit the recurrence of tumor cells, the pain symptoms of cheek bone can be effectively improved.