Pain when pressing the bone of the cheek may be caused by the following reasons: First, local aseptic inflammation: in addition to painful pressure there is no significant local swelling, and the pain may appear or increase when eating or biting. Second, problems in the oral cavity: there may be inflammation of the teeth or gums, leading to local infection, and the infected tissue affects the bone, thus appearing to have pressure pain. In this case, there will be obvious soft tissue swelling, or redness, swelling, heat and pain inside the mouth. Third, the primary problems of the cheek bone: such as primary tuberculosis, tumors and other cases, you can do local X-ray, CT to make a clear diagnosis.