Amoxicillin does not directly cause abnormal heart rate; the drug may cause adverse reactions such as euphoria and anxiety, which indirectly lead to abnormal heart rate. Amoxicillin is a penicillin antibiotic commonly used clinically for infectious diseases such as pneumonia, sinusitis, pharyngitis, soft tissue infections, and other infectious diseases caused by sensitive bacteria such as Streptococcus pneumoniae, Streptococcus hemolyticus, and Escherichia coli. There is no literature linking the drug to abnormal heart rate, so it is believed that amoxicillin does not directly cause abnormal heart rate. However, the use of this drug may lead to nausea, vomiting, drug fever, anemia, excitement, anxiety, insomnia and other adverse reactions, causing physiological dysfunction, which may indirectly lead to abnormal heart rate. The drug is contraindicated for those who are allergic to penicillins; caution is recommended during pregnancy and lactation. Amoxicillin needs to be used under the supervision of a clinician. The occurrence of the above serious adverse reactions, it is recommended to promptly go to the hospital.