The weakness of the legs after taking lipid-lowering drugs is likely to be an adverse reaction caused by the drug. At present, clinically lowering blood fat is more commonly used statin drugs, the long-term use of the drug, one of the most common adverse reactions is muscle damage, including muscle weakness, muscle pain and other two major aspects of the symptom, but also has some other symptoms. 1. Muscle weakness: you will feel weak in your limbs, your strength will become smaller, and you will not even be able to lift heavy objects. 2. Muscle pain: you will feel limb weakness or generalized pain. 3. Other: when muscle damage is further aggravated, fever and rhabdomyolysis may occur, which is life-threatening in serious cases. Therefore, when taking lipid-lowering drugs, you should always pay attention to whether you are experiencing related symptoms and seek medical treatment and follow-up in time. Drugs should be used in strict accordance with medical advice.