Callus, palmoplantar warts, palmoplantar pustulosis, etc. can be considered as small bumps on the palm similar to callus. 1. callus: if the patient palms of small bumps manifested as a slightly elevated plaque, touch hard, smooth surface and clear skin texture, yellow or waxy yellow, no self-awareness of symptoms, etc. can be considered to be a callus, that is, callus; this disease and long-term mechanical stimulation, such as friction and pressure, caused by excessive proliferation of the skin horny layer related. 2. palmoplantar warts: palmoplantar warts caused by human papillomavirus infection may also lead to callus-like bumps on the palm of the hand; this disease shows wart-like, flat, etc., most of them have no self-awareness of the symptoms, and some of them have pressure pain, tingling sensation; this disease is mainly associated with autoimmune deficiency, human papillomavirus infection and other factors. 3. Palmoplantar pustulosis: If the small bumps on the palm of the patient’s hand are pustules or brown spots, it can be considered as palmoplantar pustulosis; this disease is related to local infections (acute and chronic tonsillitis, dental infections, etc.), metal allergies, heredity, stress (emotional stress, skin trauma, etc.), and medications (long-term use of biosuppressant agents, etc.). It is recommended that patients seek timely medical attention to clarify the cause of the disease and receive appropriate treatment under the guidance of a specialized doctor.