Bumps on the cheeks of the mouth may be enlarged lymph nodes, benign tumors of the parotid gland, but cancer patients may also have cancer metastasis. 1. Enlarged lymph nodes. When the organism viral or bacterial infection, it can cause reactive enlargement of the lymph nodes in the cheeks, with several hard nodes by touching and pressing with the hand, and pain by pressing. Generally, the nodes can disappear after taking antibacterial and antiviral drugs. 2. Benign tumor of parotid gland. Bumps in the parotid cheek area of the oral cavity may be benign tumors, touching with the hand generally have no pain in the mass, movable without adhesion, no dysfunction, smooth surface or nodular, but the specific need to go to the hospital to do instrumental examination or laboratory tests to confirm the diagnosis. 3. Cancer metastasis. When there is a history of cancer such as tongue cancer, submandibular adenocarcinoma, etc., and the lumps in cheek area have the symptoms of adhesion, pressing pain, and nerve dysfunction, it can be considered that cancer metastasis may have occurred. Whether cancer metastasis occurs in the cheek or oral cavity should be diagnosed in the hospital according to the clinical manifestations, medical history and laboratory examination.