With the increased incidence of diabetes, it is now the number one cause of carpal tunnel syndrome. In contrast to the previous simple carpal tunnel syndrome (median nerve entrapment), diabetic upper extremity neuropathy also frequently involves the ulnar nerve. Symptoms: Pain and numbness in the thumb, index finger, middle or ring finger, little finger or all five fingers, often initially at night or in the early morning hours, often waking up with pain or numbness. Symptoms tend to be heaviest in the fingertips. Symptoms decrease after shaking the hand. Some patients also experience pain in the elbow joint. Subsequently, finger immobility develops, and the disease continues to progress with muscle atrophy of the hand. Diagnosis: The diagnosis is made by an experienced physician through physical examination, and electromyography is also helpful for a clear diagnosis. Treatment: 1. Brace to restrict wrist movement; wear at night or throughout the day. Mild disease – effective; 2. Oral or intramuscular injection of neurotrophic drugs – adjuvant therapy, basically ineffective alone; 3. Local injection of hormones – short-term effective, most relapses; 4. Surgery – the fundamental treatment method, minimally invasive surgery can minimize the damage and incision scar.