Girls suffering from SLE need systematic and standardized treatment, including general treatment, drug treatment, auxiliary treatment and so on. 1. General treatment: avoid all kinds of causative stimuli, such as acute and chronic infections, etc., pay attention to sunscreen, use sunscreen, etc., maintain optimism, correctly recognize the disease, eliminate fear, and have confidence in overcoming the disease. Live a regular life, combine work and rest, prevent infection, and actively cooperate with the treatment. Pay attention to contraception when the disease is active or important organs are damaged. 2. Drug therapy: For patients with lupus, hormone (e.g. methylprednisolone, prednisone, etc.) and immunosuppressant (e.g. hydroxychloroquine, cyclophosphamide, etc.) are generally used to treat lupus, but it is necessary to judge the patient’s degree of disease activity, including the mild, moderate and severe types, and to judge the existence of lupus crisis or the combination of antiphospholipid syndrome, in order to guide the treatment. 3. Adjuvant therapy: mainly includes plasma exchange, autologous stem cell transplantation, dialysis therapy and kidney transplantation, Chinese medicine and other treatments. Girls suffering from SLE are advised to consult the doctor in time and choose the appropriate treatment under the doctor’s guidance. All of the above drugs should be used under the guidance of a physician, do not use drugs blindly.