If the test is positive for Hepatitis B surface antigen and positive for Hepatitis B core antibodies, the patient is considered to be infected with Hepatitis B, and is a small two-positive for Hepatitis B. It can be treated by general treatment, non-specific hepatoprotective drug treatment, entecavir, anti-jaundice and so on. 1. General treatment: after the disease occurs, if the patient’s symptoms are obvious, he should take bed rest. After the disease improves, proper exercise is allowed. In terms of diet, it is also necessary to eat more high-protein and high-calorie food, which is good for liver health. 2. Non-specific liver-protecting drugs: After hepatitis B core antibody is positive, patients can take some non-specific liver-protecting drugs, mainly including vitamins, glucuronolactone, etc. These drugs can effectively protect and nourish the liver to avoid further damage to the liver. 3. Entecavir treatment: Entecavir is the first-line drug. This drug can effectively reduce liver dysfunction and slow down the progress of the disease. However, it is easy to develop drug resistance after taking this drug, so patients are not recommended to continue using it for a long time. 4. Anti jaundice drug treatment: after the occurrence of this disease, patients will have different degrees of jaundice symptoms. Glycyrrhizic acid preparation and reduced glutathione can be taken, which can effectively reduce jaundice. With active and standardized treatment, the prognosis of the disease is usually good, and its transformation into cirrhosis can be prevented. However, if it is not treated properly, it may develop into liver failure, cirrhosis, or even liver cancer, so it should be taken seriously. The use of medication should be under the guidance of a doctor.