The epidemiological data of liver and hepatocellular carcinoma show that China is a country with high incidence of liver cancer, with 90 million hepatitis B virus carriers, 54% of liver cancer cases worldwide, and 370,000 patients dying of liver cancer every year. General knowledge about the liver The liver is the largest gland within the human body, and it is divided into the left and right lobes. Most of the liver has no nerve distribution, only the external peritoneum and large ducts have innervations and are sensitive to pain, so liver tumors only cause pain when they grow to the peritoneum or press on the large ducts. Liver has unique and important physiological functions in the metabolism of sugar, protein, fat and energy metabolism of human body, in addition, it also participates in vitamin metabolism and bioconversion, and plays an irreplaceable role in maintaining the metabolic balance of human body. The liver is one of the organs with the fastest rate of protein synthesis in the body, and it can synthesize most of the plasma proteins except immunoglobulin. The liver maintains a relatively constant blood glucose concentration through several pathways. Hepatocytes synthesize and secrete bile acid salts, which are excreted into the digestive tract via the bile ducts and are called bile. If the tumor blocks or compresses the large bile ducts, blocking the bile and returning it to the bloodstream, it can lead to obstructive xanthomas, which causes yellowing of the skin and sclera. So the presence of gangrene is a sign of liver disease. Liver also has an important role is the role of biological transformation, normal human body in the material metabolism produces a variety of biologically active substances, metabolic end-products, or from outside the body into the drugs, food additives and other chemicals, etc., all need to metabolize the transformation of the liver, in order to facilitate the excretion. In short, the liver is one of the most important organs for sustaining life activities. Symptoms or Problems to be Aware of Since there is no pain sensation due to the lack of nerves in the liver, early symptoms of liver cancer are not obvious or even symptomless. As the disease progresses, there will be some slight pain or discomfort in the upper right (sometimes in the center) of the abdomen, which is usually very mild and much like indigestion. Of course indigestion is very common and should not be considered as a sign of liver cancer progression. The next stage is moderate or severe pain in the upper right, middle and back of the abdomen. The more common first symptoms of liver cancer are pain in the liver area, weakness, loss of appetite, bloating and weight loss (especially muscle atrophy in the extremities), sometimes accompanied by mild nausea. With the exception of liver pain, all symptoms are easily confused with other diseases. By the time symptoms of gangrene, ascites, abdominal masses or distant metastases appear, the disease is already at an advanced stage. Vomiting blood and black stools are also more common.