The difference between benzoxicillin and amoxicillin is that the flora covered is not the same and the strength is not the same. Benzoxicillin and amoxicillin both belong to the penicillin class of drugs, benzoxicillin is mainly acid and penicillinase resistant penicillin, while amoxicillin is more widely used, targeting more strains of bacteria. Benzoxicillin is mainly used for pneumonia and soft tissue infections caused by penicillin-resistant staphylococcus bacteria, while amoxicillin is suitable for infections caused by sensitive bacteria, such as upper respiratory tract infections, genitourinary tract infections, soft tissue skin infections, lower respiratory tract infections and so on. Benzoxicillin and amoxicillin can cause nausea, vomiting, abdominal distension, loss of appetite and skin rash and other adverse reactions, penicillin allergy and penicillin skin test positive patients should be prohibited from using this kind of drug. Benzoxicillin and amoxicillin should be used under the guidance of a doctor, do not blindly use the drug, so as not to cause adverse consequences.