Menstruation has not been coming and not pregnant may be physiological, may be related to pathological factors such as reproductive system tuberculosis, inflammation, ovarian dysfunction, polycystic ovary syndrome, tumors and so on. 1. Physiological factors: such as staying up late, excessive stress, anxiety, tension and other bad habits and emotions, women approaching menopause, etc. may appear physiological menstrual delay or amenorrhea. 2. Pathological factors (1) Tuberculosis of the reproductive system: mostly related to the hematogenous spread of tuberculosis, which may cause dysfunction of the ovarian tissues, resulting in delayed menstruation and other symptoms. It is often accompanied by symptoms such as low fever, night sweating and generalized emaciation. (2) Inflammation: such as chronic cervicitis retrograde infection of endometritis, which destroys the endometrium, thus causing prolonged menstrual cycle or even amenorrhea, lumbago and other symptoms. (3) Ovarian dysfunction: such as excessive weight loss, cold drinks, medicines and other factors lead to abnormalities in the function of the hypothalamic-pituitary-ovarian axis, endocrine disorders, resulting in menstrual disorders, delayed menstruation or even amenorrhea than the symptoms. (4) Polycystic ovary syndrome: in addition to delayed menstruation or amenorrhea, it is often accompanied by acne, hairiness and other hyperandrogenic symptoms (5) Tumors: such as pituitary or ovarian tumors. Tumors: such as pituitary or ovarian tumors, etc. can cause endocrine abnormalities, and there are no obvious symptoms in the early stage, but with the development of the disease, symptoms such as delayed menstruation or even menopause can occur. It is recommended that women who are not pregnant and have delayed menstruation should go to the hospital in time to improve the hormone six tests and actively treat the cause of the disease, so as to avoid delaying the condition.