One third of a person’s life is spent in sleep, and the quality of sleep is closely related to the quality of life, especially for kidney patients. Insufficient sleep and poor sleep quality may induce or aggravate chronic kidney injury, especially for patients with hypertension, diabetes and obstructive sleep apnea syndrome, who may suffer from chronic hypoxia for a long time, which may lead to prolonged or progressive aggravation of kidney disease. Staying up all night not only brings about sleep deprivation, but also disrupts the body’s biological clock, causing the physiological functions of each organ in the human body to become chaotic. The so-called biological clock, also known as the physiological clock, it is an invisible “clock” in the organism, in fact, is the internal rhythm of the organism’s life activities, which is determined by the organism’s time structure order. That is to say, the human body’s behavior and the physiological function of the organs (hormone secretion, sleep, body temperature and metabolism) regulated by the biological clock, once the biological clock is disrupted, will cause disorders in the physiological function of the human body’s organs as well as a decline in the body’s immunity, which will cause a series of diseases in the long run. This year (2017) three U.S. scientists for the discovery and explanation of how plants, animals and humans through the regulation of biological rhythms, and the rotation of the Earth to achieve synchronization, which is often referred to as the phenomenon of biological clock and won the Nobel Prize in Physiology or Medicine. The results of this Nobel Prize suggest that when our lifestyle is always against our body’s internal “timer”, the risk of various diseases may increase. Kidneys are one of the largest workload organs in the human body, but it is extremely poor tolerance to ischemia and hypoxia, once the normal sleep patterns continue to be disrupted, the structure of the kidney tissue and the production of physiological functions will cause permanent damage. Staying up all night on the kidney damage is highlighted in the following aspects: Harm one, accelerate the loss of renal units The structure of the kidney is a high-running filter, which works like the rotational speed of a car engine. If you let it continue to run at high speed, it is bound to lead to its accelerated destruction. Kidney disease patients who often stay up late tend to deteriorate kidney function significantly faster than normal sleepers. Injury two, induced obesity, aggravate the burden of kidney unit Stay up late people often eat “late-night snacks”, not only difficult to digest, the next morning will also be loss of appetite, resulting in nutritional imbalance, causing obesity. The relationship between obesity and kidney disease has been clearly established. Injury three, the decline in immunity Often in the late-night, fatigue, mental instability, the body’s immunity will follow the decline in colds, allergies, etc. will find your head unannounced. Harm four, the risk of heart disease Long-term “black and white” people, not only the temper will become bad, the internal organs can not be adjusted in a timely manner, so that the chances of heart disease. Kidney disease patients who often stay up late, although actively taking medication, but often found proteinuria negative difficult, blood pressure, blood sugar control is difficult to meet the standard, weight loss is also difficult to do the difficult situation. This emphasizes that patients with kidney disease, especially those with hypertension, diabetes and obstructive sleep apnea syndrome, should not stay up late. Staying up all night will not only make their condition untreated, but will also cause other reasons for frequent occurrence of cardiovascular and cerebrovascular comorbidities that make the lesions more complicated and more difficult to treat, and even lead to sudden death.