Periumbilical discoloration is one of the signs of acute hemorrhagic necrotizing pancreatitis. Acute hemorrhagic necrotizing pancreatitis is a type of acute pancreatitis, which is caused by the continued development of acute edematous pancreatitis lesions. There is extensive necrosis of pancreatic alveoli, fat and blood vessels, edema of pancreatic tissue, increase in size, and extensive hemorrhagic necrosis. The retroperitoneal space is heavily hemorrhagic with exudate. The omentum and tissues of the lining are digested by the exuded pancreatic enzymes. This type of pancreatitis is severe and develops rapidly, with many complications and high mortality. What are the tests for peribulbar discoloration? 1, pancreatic stimulation test intravenous injection of intestinal pancreatic peptide, cholestyramine – cholestyramine or rain frog peptide can stimulate pancreatic secretion, remove pancreatic fluid from the duodenal drainage tube on time, observe the amount of pancreatic fluid, sodium bicarbonate and various pancreatic enzymes secretion. When chronic pancreatitis, the amount of secretion is reduced. 2, PABA test is simpler but less sensitive and subject to more factors. It is easy to have positive results if the pancreatic function is more severely damaged. 3.Fecal chymotrypsin assay has decreased in 49% of patients with early chronic pancreatitis and has decreased significantly in 80% to 90% of patients with severe advanced chronic pancreatitis. 4, cholesterol-13c-octanoic acid breath test is also a non-invasive method to check the exocrine function of the pancreas, and can be measured by exhaled 13c-labeled C02 if pancreatic secretion of cholinesterase is reduced. Its sensitivity and specificity are good. 5, radioimmunological methods The determination of CCK-PZ content in blood is useful for the diagnosis of chronic pancreatitis. The normal fasting is 60pg/ml, and up to 8000pg/ml in patients with chronic pancreatitis. this is due to reduced pancreatic enzyme secretion in chronic pancreatitis, and the feedback inhibition of CCK-PZ secreting cells is weakened.