It is generally not recommended to give hepatitis B vaccine that is not produced by the same manufacturer because although the method of producing hepatitis B vaccine is generally similar among manufacturers, the inactivation method may be different, and the inactivation method has an effect on the immunization effect of the vaccine, and the dose of the vaccine may be different from one manufacturer to another. Therefore, to ensure the standardization of the operation and to avoid entanglement after adverse reactions, it is best to use the same manufacturer and batch of hepatitis B vaccine. In addition, the following matters should be noted before and after the hepatitis B vaccination: 1. Before vaccination: Be sure to check the hepatitis B virus surface antigen (HBsAg), surface antibody (anti-HBs), e antigen (HBeAg), e antibody (anti-HBe) and core antibody (anti-HBc), which is often referred to as the hepatitis B “two pairs of half”. “For example, those who are all negative need to be injected with hepatitis B vaccine to produce surface antibodies (anti-HBs), while those who are positive for surface antibodies (anti-HBs) do not need to be injected; 2. Within 3 days afterwards, you should avoid excessively spicy and stimulating food, avoid excessively strenuous exercise, quit smoking and alcohol, and avoid getting water on the vaccination site. The hepatitis B vaccination generally lasts only 10-12 years, and the antibody titers will be checked later, and the vaccination will be reinforced under the guidance of the doctor according to the results.